Researchers in Vienna have conducted small clinical st lucia weather trials using intravenous formu

Home Subscription InfoTraitements What I think Echoes of the helpline association Editorials st lucia weather Events / Go to Membership Partners & Associations Treatments Trials Management Protocols Products Adverse

Reactions treatments Opportunistic Diseases Living with coinfections Prevention Diagnostics & Testing Support st lucia weather supports Quality of Life Sexuality Women Kids Legislation Surveys Participate Donate Testimonials Multimedia Live from ... Photo Gallery Podcasts Shares Treatments Questions and Answers Links Download News News HIV & Society Congress & Meetings Our meetings Press Press Releases

Caution current therapeutic HIV is evolving rapidly, it is possible that the article below is no longer valid. Thank you to consider as a priority the most recent articles. The thistle-relief possible for people with hepatitis C (CATIE News, 27jan09)
Milk thistle is a plant used for centuries as a traditional remedy for the European gastrointestinal diseases and liver. This plant contains many compounds, some of which are studied in the context of laboratory experiments on cells. In these experiments, extracts of milk thistle appear to have anti-inflammatory, anticancer and antioxidant properties. In addition, some extracts have antiviral st lucia weather activity against hepatitis C virus (HCV). All these properties have increased interest for this plant,

as well as extensive research.
Researchers in Vienna have conducted small clinical st lucia weather trials using intravenous formulation of an extract of milk thistle, silibinin in patients with hepatitis C who did not respond to conventional therapy. Their results are somewhat surprising and suggest that silibinin has potent activity against HCV in some people. Much remains to be done to confirm and extend these findings.
For the study, 36 volunteers (5 women and 31 men) were recruited. All suffered from HCV mono-infection and earlier, the usual treatment of HCV is a combination of immune interferon and the antiviral drug ribavirin, had proved ineffective. The average age of the subjects was 50 years and most were infected with HCV strains are difficult to treat, or genotype 1. Approximately 55% of these individuals had suffered liver damage ranging from moderate to severe. st lucia weather
The research team administered to participants different intravenous doses of highly purified silibinin, sold under the name Sil Legalon (manufactured by Madaus GmbH, Cologne, Germany) for one to two weeks, followed by the combination of interferon and ribavirin. In addition, after ceasing st lucia weather to administer intravenous silibinin participants, the researchers gave an oral formulation of a mixture of extracts of milk thistle called silymarin. This formulation was administered orally three times per day. To date, most of the participants received st lucia weather silymarin and interferon-ribavirin for 24 weeks and the study will continue for 24 more weeks.
High doses, 15 or 20 mg / kg / day of silibinin alone, administered intravenously, resulted a significant decrease (between 100 - and 10,000-fold) levels of HCV. The addition of interferon-ribavirin was falling further levels of HCV.
In two of the five participants who received 15 mg / kg / day IV silibinin, the level of HCV has dropped below the detection limit or the lower limit of quantification set at 15 international units (IU). Five of the nine participants who received 20 mg / kg / day also saw their HCV levels fall below 15 IU.
In general, intravenous silibinin was well tolerated. Eight participants complained of the following symptoms (some participants st lucia weather had more than one symptom), each described as "light":
All participants who received high doses of intravenous silibinin reported a sensation of heat during infusion of the preparation, and this effect faded after 30 minutes.
In this study, intravenous silibinin seemed to have a powerful anti-HCV activity. However, according to the research team, oral doses of extracts of milk thistle did not have the same effect. The team suspects that this is likely due to metabolism imports